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		BIONOVO, INC. $0.145 (-0.002) NASDAQ: BNVI

Publications

Bionovo Publications

Saunier, E., Vivar, O., Rubenstein, A., Zhao, X., Olshansky, M., Baggett, S., Staub, R., Tagliaferri, M., Cohen, I., Speed, T., Baxter, J., Leitman, D. Estrogenic Plant Extracts Reverse Weight Gain and Fat Accumulation without Causing Mammary Gland or Uterine Proliferation. PLoS ONE 6(12): e28333. doi:10.1371/journal.pone.0028333. December 7, 2011.
Klawitter, J., Klawitter, J., Gurshtein, J., Corby, K., Fong, S., Tagliaferri, M., Quattrochi, L., Cohen, I., Shtivelman, E. and Christians, U. Bezielle (BZL101)-Induced Oxidative Stress Damage Followed by Redistribution of Metabolic Fluxes in Breast Cancer Cells: A Combined Proteomic and Metabolomic Study. International Journal of Cancer. doi: 10.1002/ijc.25965. April 20, 2011.
Chen, V., Shtivelman, E. CC3/TIP30 Regulates Metabolic Adaptation of Tumor Cells to Glucose Limitation. Cell Cycle. 9:24. Published online ahead of print December 15, 2010.
Paruthiyil, S., Cvoro, A., Tagliaferri, M., Cohen, I., Shtivelman, E., Leitman, D.C. Estrogen Receptor β Causes a G2 Cell Cycle Arrest by Inhibiting CDK1 Activity Through the Regulation of Cyclin B1, GADD45A, and BTG2. Breast Cancer Research and Treatment. Breast Cancer Res Treat. 2010 Dec 1. [Epub ahead of print].
Leitman, D.C., Paruthiyil, S., Vivar, O.I., Saunier, E.F., Herber, C.B., Cohen, I., Tagliaferri, M., Speed, T.P. Regulation of Specific Target Genes and Biological Responses By Estrogen Receptor Subtype Agonists. Current Opinion in Pharmacology. Published online ahead of print October 14, 2010. doi:10.1016/j.coph.2010.09.009.
Zhang, L., Blackman, B.E., Schonemann, M.D., Zogovic-Kapsalis, T., Pan, X., Tagliaferri, M., Harris, H.A., Cohen, I., Reijo Pera, R.A., Mellon, S.H., Weiner, R.I., Leitman, D.C. Estrogen Receptor β-Selective Agonists Stimulate Calcium Oscillations in Human and Mouse Embryonic Stem Cell-Derived Neurons. PLoS ONE 2010 Jul 28. 5(7): e11791. doi:10.1371/journal.pone.0011791
Vivar, O.I., Zhao, X., Saunier, E., Griffin, C., Mayba, O.S., Tagliaferri, M., Cohen, I., Speed, T., Leitman, D.C., Estrogen Receptor [beta] Binds to and Regulates Three Distinct Classes of Target Genes, The Journal of Biological Chemistry. 2010 April 19. [Epub ahead of print].
Perez, A.T., Arun, B., Tripathy, D., Tagliaferri, M.A., Shaw, H.S., Kimmick, G.G., Cohen, I., Shtivelman, E., Caygill, K.A., Grady, D., Schactman, M., Shapiro, C.L.. A Phase 1B Dose Escalation Trial of Scutellaria Barbata (BZL101) for Patients with Metastatic Breast Cancer. Breast Cancer Research and Treatment. 2010 Jan 7. [Epub ahead of print].
Chu, R., Zhao, X., Griffin, C., Staub, R., Shoemaker, M., Climent, J., Leitman, D.C., Cohen, I., Shtivelman, E., Fong, S. Selective Concomitant Inhibition of mTORC1 and mTORC2 Activity in Estrogen Receptor-Negative Breast Cancer Cells by BN107 and Oleanolic Acid. International Journal of Cancer. 2009 Dec 21. [Epub ahead of print].
Tagliaferri, M., Stein, H., Caygill, K., Olyaie, A., Zhao, X., Cohen, I. Physicians' Opinions Regarding Treatment with Hormone Therapy, Antidepressants and a Novel Estrogen Receptor Beta Agonist, Menerba for Vasomotor Symptoms. Panel Intelligence. Cambridge, Massachusetts, 2009 Oct 12.
Levy, N., Paruthiyil, S., Zhao, X., Vivar, O.I., Saunier, E.F., Griffin, C., Tagliaferi, M., Cohen, I., Speed, T.P., Leitman, D.C. Unliganded Estrogen Receptor-beta Regulation of Genes is Inhibited by Tamoxifen. Molecular and Cellular Endocrinology. 2009 Sep 8. [Epub ahead of print].
King, F.W., Fong, S., Griffin, C., Shoemaker, M., Staub, R., Zhang,Y.L., Cohen, I., Shtivelman, E. Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress. PLoS ONE 4(9): e7283. doi:10.1371/journal.pone.0007283.
Paruthiyil, S., Cvoro, A., Zhao, X., Wu, Z., Sui, Y., et al. Drug and Cell Type-Specific Regulation of Genes with Different Classes of Estrogen Receptor Beta-Selective Agonists. PLoS ONE 4(7): e6271. doi:10.1371/journal.pone.0006271, 2009.
Grady, D., Sawaya, G., Johnson, K.C., Koltun, W., Hess, R., Vittinghoff, E., Kristof, M.,Tagliaferri, M., Cohen, I., Ensrud, K.E, MF101, A Selective Estrogen Beta Receptor Modulator for the Treatment of Menopausal Hot Flushes: A Phase II Clinical Trial. Menopause, 2009 Jan 29. [Epub ahead of print].
Ball, L., Levy, N., Zhao, X., Griffin, C., Tagliaferri, M., Cohen, I., Ricke, W., Speed, T., Firestone, G., Leitman, D.C. Cell Type- and Estrogen Receptor-Subtype Specific Regulation of Selective Estrogen Receptor Modulator Regulatory Elements. Molecular and Cellular Endocrinology, 2009 Feb 27;299(2):204-11. Epub 2008 Nov 18.
Kupfer, R., Swanson, L., Chow, S., Staub, R., Zhang, Y.L., Cohen, I., Christians, U . Oxidative In Vitro Metabolism of Liquiritigenin, a Bioactive Compound Isolated from the Chinese Herbal Selective Estrogen Beta-Receptor Agonist MF101. American Society for Pharmacology and Experimental Therapeutics, Published on July 31, 2008 as doi:10.1124/dmd.108.021402.
Fong, S., Shoemaker, M., Cadaoas, J., Lo, A., Liao, W., Tagliaferri, M., Cohen, I., Shtivelman, E. Molecular Mechanisms Underlying Selective Cytotoxic Activity of Bezielle, an Extract of Scutellaria Barbata, Towards Breast Cancer Cells. Cancer Biology and Therapy. 7;7(4), 2008.
Mersereau, J.E., Levy, N., Staub, R.E., Baggett, S., Zogric, T., Chow, S., Ricke, W.A., Tagliaferri, M., Cohen, I., Bjeldanes, L.F., Leitman, D.C. Liquiritigenin is a Plant-Derived Highly Selective Estrogen Receptor β Agonist. Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2007.11.020.
Cvoro, A., Paruthiyil, S., Jones, J., Tzagarakis-Foster, C., Clegg, N., Tatomer, D., Medina, R., Tagliaferri, M., Schaufele, F., Scanlan, T., Diamond, M., Cohen, I., Leitman, D.C. Selective Activation of Estrogen Receptor β Transcriptional Pathways by an Herbal Extract. Endocrinology. Vol. 148, No. 2 538-547. doi:10.1210/en.2006-0803, 2007.
Rugo, H., Shtivelman, E., Perez, A., Vogel, C., Franco, S., Tan Chiu, E., Melisko, M., Tagliaferri, M., Cohen, I., Shoemaker, M., Tran, Z., Tripathy, D. Phase I Trial and Antitumor Effects of Bezielle for Patients With Advanced Breast Cancer. Breast Cancer Research and Treatment. First published ahead of print as DOI 10.1007/s10549-006-9430-6.
Shoemaker, M., Hamilton, B., Dairkee, S.H., Cohen, I., Campbell, M.J. In Vitro Anticancer Activity of Twelve Chinese Medicinal Herbs. Phytother Res 19 (7): 649-651, 2005.
Shoemaker, M., Cohen, I., Campbell, M. Reduction of MTT by Aqueous Herbal Extracts in the Absence of Cells. J Ethnopharmacol 93: 381-384, 2004.
Powell, B.C., Fung, P., Jackson, J., Dall'Era, J., Lewkowicz, D., Cohen, I., Smith-McCune, K. Aqueous Extract of Herba Scutellaria Barbatae, a Chinese Herb Used for Ovarian Cancer, Induces Apoptosis of Ovarian Cancer Cell Lines. Gynecol Oncol 91: 332-340, 2003.
Cohen, I., Tagliaferri, M., Tripathy, D. Traditional Chinese Medicine in the Treatment of Breast Cancer (Part Three). Journal of Chinese Medicine, October 2002, 44-54.
Cohen, I., Tagliaferri, M., Tripathy, D. Traditional Chinese Medicine in the Treatment of Breast Cancer (Part Two). Journal of Chinese Medicine, June 2002, 49-53.
Cohen, I., Tagliaferri, M., Tripathy, D. Traditional Chinese Medicine in the Treatment of Breast Cancer (Part One). Journal of Chinese Medicine, February 2002, 40-49.
Campbell, M., Hamilton, B., Shoemaker, M., Tagliaferri, M., Cohen, I., Tripathy, D. Antiproliferative Activity of Chinese Medicinal Herbs on Breast Cancer Cells in Vitro. Anticancer Res 22: 3843-3852, 2002.
Powell, C.B., Dibble, S.L., Dall'Era, J.E., Cohen, I. Use Of Herbs In Women Diagnosed with Ovarian Cancer. Int J Gynecol Cancer. 2002 Mar-Apr;12(2):214-7.
Tagliaferri, M., Cohen, I., Tripathy, D. Complementary and Alternative Medicine in Early Stage Breast Cancer. Semin Oncol 28 (1): 121-134, 2001.

FDA Guidance Documents

U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research. Guidance for Industry Botanical Drug Products. June 2004.
U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research. Guidance for Industry: Estrogen and Estrogen/Progestin Drug Products to Treat Vasomotor Symptoms and Vulvar and Vaginal Atrophy Symptoms - Recommendations for Clinical Evaluation. January 2003.

Bionovo Research Related Publications

Stovall, D.W., Pinkerton, J.V. MF-101, An Estrogen Receptor beta Agonist for the Treatment of Vasomotor Symptoms in Peri- and Postmenopausal Women. Current Opinion in Investigational Drugs. 2009 Apr;10(4):365-71.
Cvoro, A., Tatomer, D., Tee, M-K., Zogric, T., Harris, H. A., Leitman, D.C. Selective Estrogen Receptor-β Agonists Repress Transcription of Proinflammatory Genes. Journal of Immunology 180: 630–636, 2008.
Levy, N., Tatomer, D., Herber, C. B., Zhao, X., Tang, H., Sargeant, T, Ball, L., Summers, J., Speed, T. P, Leitman, D.C. Differential Regulation of Native Estrogen Receptor-Regulatory Elements by Estradiol, Tamoxifen and Raloxifene. Molecular Endocrinology 22:287-303, 2008.
Levy, N., Zhao, X., Tang, H., Jaffe, R. B., Speed, T. P., Leitman, D. C. Multiple Transcription Factor Elements Collaborate with ERα to Mediate Transcriptional Activation By Estradiol and SERMs. Endocrinology 148:3449-3558, 2007.
Cvoro, A., Tzagarakis-Foster, C., Tatomer, D., Paruthiyil, S., Fox, M., Leitman, D. C. Distinct Roles of Unliganded and Liganded Estrogen Receptors in Transcriptional Repression. Molecular Cell 21, 555-564, 2006.
Clegg, N. J., Paruthiyil, S., Leitman D. C., Scanlan, T. S. Differential Response of Estrogen Receptor Subtypes to 1,3-diarylindene and 2,3-diarylindene Ligands. J Medicinal Chemistry 48:5989-6003, 2005.
Cheng, G., Weihua, Z., Warner, M, Gustafsson, J.-Å. Estrogen Receptors ER alpha and ER beta in Proliferation in the Rodent Mammary Gland. Proc. Natl. Acad. Sci. USA 101:, 3739-3746, 2004.
Tee, M.K., Rogatsky, I., Tzagarakis-Foster, C., Cvoro, A., An, J., Christy, R., Yamamoto, K., Leitman, D.C. Estradiol and Selective Estrogen Receptor Modulators Differentially Regulate Target Genes with Estrogen Receptor α and β. Mol Biol Cell 15: 1262-1272, 2004.
Paruthiyil, S., Parmar, H., Kerekatte, V., Cunha, G., Firestone, G., Leitman, D.C. Estrogen Receptor β Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G2 Cell Cycle Arrest. Cancer Research 64, 423-428, 2004.
Gustafsson, J.-Å. What Pharmacologists Can Learn From Recent Advances in Estrogen Signaling. Trends Pharmacol. Sci. 24:, 479-485, 2003.
Tzagarakis-Foster, C., Geleziunas, R., Lomri, A., An, J. Estradiol Represses Human T-cell Leukemia Virus Type 1 Tax Activation of Tumor Necrosis Factor-α Gene Transcription. J Biol Chem 277 (47): 44772-44777, 2002.
An, J., Tzagarakis-Foster, C., Scharschmidt, T., Lomri, N., Leitman, D.C. Estrogen Receptor β-Selective Transcriptional Activity and Recruitment of Coregulators by Phytoestrogens. J Biol Chem 276 (21): 17808-17814, 2001.
Mueller, M. D., Vigne, J. L., Minchenko, A., Lebovic, D. I., Leitman, D. C., R. N. Taylor. Regulation of Vascular Endothelial Growth Factor (VEGF) Gene Transcription by Estrogen Receptors alpha and beta. Proc. Natl. Acad. Sci. USA 97:10972-10977, 2000.
Baker, V. L., Leitman, D., and R. B. Jaffe. Selective Estrogen Receptor Modulators in Reproductive Medicine and Biology. Obstet. Gynecol. Survey, 55:S21-47, 2000.
An, J., Ribeiro, R., Webb, P., Gustafsson, J.A., Kushner, P., Baxter, J., Leitman, D.C. Estradiol Repression of Tumor Necrosis Factor-α Transcription Requires Estrogen Receptor Activation Function-2 and is Enhanced by Coactivators. PNAS 96 (26):15161-15166, 1999.
Paech, K., Webb, P., Kuiper, G.G., Nilsson, S., Gustafsson, J., Kushner, P.J., Scanlan, T.S. Differential Ligand Activation of Estrogen Receptors ER alpha and ER beta at AP1 Sites. Science. 1997 Sep 5;277(5331):1508-10.
Kuiper, G. G. J. M., Enmark, E., Pelto-Huikko, M., Nilsson, S., Gustafsson, J.-Å. Cloning of a Novel Receptor Expressed in Rat Prostate and Ovary. Proc. Natl. Acad. Sci. USA 93:, 5925-5930, 1996.
Leitman, D. C., Ribeiro, R. C. J., Mackow, E. R., Baxter, J. D., West, B. L. Identification of a Tumor Necrosis Factor Responsive Element in the Tumor Necrosis Factor-alpha Gene. J. Biol. Chem. 266:9343-9346, 1991.